Analytical Resources

Analytical Resources

Analytical Resources

In order to fulfill our clients’ requirements and the
stringent demands of the pharmaceutical regulatory bodies, we employ a
substantial range of analytical testing equipment.

High
Performance Liquid Chromatography Systems (HPLC)

Pharmalytic employs state of the art systems from world
leading manufacturers, including </span>Perkin
Elmer
, Hewlett
Packard
,
.

Detectors available

Diode array

Variable UV wavelength

Fluorescence

Refractive Index

Electrochemical

Evaporative light scattering

Systems have quaternary solvent delivery pumps

Autosamplers

All systems have either 145 or 225 place autosamplers

Data Management

All integration performed by </span>Perkin
Elmer
Turbochrom
4 Software
.

Capillary
Electrophoresis

P/ACE system 5000 Capillary
Electrophoresis
with UV detection, autosampler
and data handling system. </span>

Gas
Chromatography

Autosystems
with FID detection. 82 place autosamplers

Headspace analyser coupled to GC

Integration using Perkin Elmer Turbochrom 4 software

Spectrometry

Atomic Absorption flame spectrophotometer – Trace metals analysis

Spectrum 1 Fourier Transform Infra Red spectrophotometer 

Lambda 40 UV / Visible scanning spectrophotometer

HP 8453 UV spectrophotometer with sipper unit and interchangeable path length
cell holders

Inhalation
testing equipment


(28.3L / 60L) 

Fifty Dose-to-patient glassware
sets

Micromanometer and laminar flow element for set-up of Andersen and DTP
glassware

ICH
Stability storage facilities

  • – 80В°C Freezer
  • – 20В°C Freezer
  • 4В°C
  • 5В°C
  • 5 large stability cabinets dedicated to client requirements
  • 50В°C
  • 25В°C / 60%RH Room
  • 30В°C / 60%RH Room
  • 40В°C / 75%RH Room
  • Accelerated light cabinet
  • Photostability cabinet

Dissolution

Automated </span>dissolution
apparatus
with UV diode array detector / HPLC
ultra violet detector

Dissolution apparatus with automated fraction collector for HPLC / UV
analysis

Dissolution apparatus for use with HPLC / UV analysis

Total
Organic Carbon determination

Labtoc Total Organic
Carbon (TOC) analyser
with 48 / 90 position autosampler.

Particle
Size Analysis

Malvern</span> 2600 laser diffraction particle
sizer

Malvern</span> Mastersizer S laser diffraction
particle size analyser

Optical Microscope

Blaine-Fischer sub-sieve particle sizer

Zymark

Zymark Tablet Processing
Workstation II

Physical
Testing

Micromatch Colour measurement equipment

Tablet hardness, disintegration, friability testers

Rheometry equipment (Brookfield Viscometer and Ubbelohde tubes)

Tap density machine

Chemical
Testing

Karl Fischer titrimetric water analyser

Water activity meter

Auto titrator

Osmolality meter

Hyphenated
and additional techniques

The following techniques are available through strategic and
approved arrangements with Universities and Experts in these fields.

Mass spectrometry</span> – LC-APCI, LC
– Electrospray, GC-MS

NMR – Solution state, Solid state

Differential scanning calorimetry

X-Ray powder diffraction

Raman spectroscopy

Scanning Electron Microscopy with energy dispersive X-ray
analysis

Atomic absorption / emission spectrometry – flame /
graphite furnace

Elemental analysis

Single/multiple anion analysis by Dionex

Microbiological
testing

Microbial limits testing

Total plate counts for yeasts and moulds

Preservative challenge testing

Antibiotic effectiveness testing

Endotoxin analysis using kinetic / LAL methods

Organism detection by biochemical and FAME analysis

Viable particle counts for process air systems

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